Gary Kirsten has decided to step down as Pakistan's white-ball coach just a week before the upcoming Australia ODIs and T20Is.
"Erik ten Hag has left his role as Manchester United men's first-team manager," said a club statement.
"Erik was appointed in April 2022 and led the club to two domestic trophies, winning the Carabao Cup in 2023 and the FA Cup in 2024."
"We are grateful to Erik for everything he has done during his time with us and wish him well for the future."
"Ruud van Nistelrooy will take charge of the team as interim head coach, supported by the current coaching team, whilst a permanent head coach is recruited."
Ten Hag's job was under scrutiny since last season but a win in FA Cup last season kept him in his post. The ongoing season, however, turned out to be the worst start for the United ever since 1989/90 even before the West Ham loss on Sunday.
The 54-year-old Ten Hag's position had been repeatedly called into question in recent week after United co-owner Jim Ratcliffe kept him on board at Old Trafford following the club's FA Cup final win over Manchester City at Wembley in May.
(With inputs from agencies)